The Saracens have chosen to pursue domestic success this season across the continental ambitions.
The three-time Champions Cup winners have decided to rest for a trip to Toulon, including Maroitoge and Tom Willis.
Rugby Mark McCall director says he prioritizes the Premiership playoffs for his chances in the fourth European crown.
Meanwhile, the Northampton Saints are the only English side with a home tie after finishing the top of Pool 3.
The Saints are in eighth place in the Premiership table after enduring the disastrous defense of their title, but Phil Dowson’s side will host Clermont with a welcome reprieve from the domestic campaign.
Visitors are sixth in France’s top 14 tables after their recent victory over La Rochelle concluded their league defeats for five consecutive times.
Clermont booked their place in the knockout stage by snatching a dramatic 33-26 victory in six minutes of overtime to qualify at Bath and Bristol’s expenses.
Elsewhere, Sale Sharks faces a difficult trip to Toulouse, six-time winners and defending champions. Toulouse will be without injured talisman Antoine DuPont after ruptured the cruciate ligament in his knee when the six French nations won last month in Ireland.
The Harlequins face equally difficult tasks with four-time winner Rainster, and the Leicester Tigers travel north to face the Glasgow Warriors.