The Detroit Tigers will host the Chicago White Sox at Friday’s day game and open the weekend series. The game will serve as the Tigers’ home opener. Both teams enter with matching overall records of 2-4. Chicago has been streaked in back-to-back defeats to the Minnesota Twins, looking for a first series victory of the season. The Tigers won two of their three games against the Seattle Mariners, but lost the series finale 3-2 on Wednesday. Jonathan Cannon is set to start for the White Sox, and Jack Flaherty is on the Tigers’ mound.
The first pitch at Comerica Park in Detroit is set at 1:10pm ET. Detroit is the latest White Sox vs Sportsline Consensus Tigers odds, with the -253 favorite (risk of winning $100) on the money line. The over/under run, or total number of runs that Vegas is likely to be scored, is 7. Before you create a Tigers vs. White Sox pick, betting advice from MLB predictions and sportsline’s proven computer simulation models.
The Sportsline Projection Model simulates all MLB games 10,000 times. In the second week of the 2025 MLB season, you will be in the 34-18 roll with the highest rated line bet pick (+729). Anyone who follows the Sportsbooks or the Betting app may have seen a strong return.
Currently, the model is aiming for the Tigers vs. White Sox, trapped in the predictions of the pick and MLB. Head to SportsLine now to see the model picks. Well, here are some MLB odds and betlines for the White Sox vs. Tigers:
Tigers vs. White Sox Money Line: Detroit-253, Chicago +206 Caesars Sportsbook Tegers vs. White Sox Over/Under: 7 Run Tigers vs. White Sox Run Line: White Sox-1.5 (-110) Tigers vs. White Sox Pick
Why the Tigers can cover it
The Tigers are motivated to play well in front of the home crowd in the first game of the season at Comerica Park. After being swept by the Los Angeles Dodgers in the first series of the season, Detroit bounced back and won two of three games against the Seattle Mariners. The Tigers hit the ball well as a team.
Leading the path to Detroit is leaving fielder Riley Green. The 24-year-old hits .296 with two home runs and three RBIs. Detroit’s expected starter on Friday was Jack Flaherty, who made it to 5.2 innings and allowed three hits and two to score on five strikeouts against the Dodgers in the first start of the season. Take a look at the teams returning to the Sports Line.
Why White Sox can cover
The White Sox made a great contribution from the pitching staff early in the season. Chicago will enter this matchup with a team ERA of 2.83, the sixth highest number in MLB. The White Sox opponents hit .201 against the team’s pitching staff, and the team has a collective whip of 1.06.
Jonathan Cannon will make his second start of the Chicago season. In his first start, the 24-year-old right-hander went into 5.0 innings, allowing four hits and zero runs while talliing five strikeouts. Left fielder Andrew Benintendy paced Chicago’s offense, hitting .333 with two home runs and six RBIs. Take a look at the teams returning to the Sports Line.
How to make a White Sox and Tigers pick
Sportsline’s model leaps towards the total execution, saying that one side of the money line has all its value. You can head to SportsLine to see the Model’s MLB picks.
So who won the White Sox vs. Tigers on Friday? Go to SportsLine now to see which side you need to jump from the model that crushed the MLB pick.
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